Improving risk stratification for infarction related sudden cardiac death by combining cardiac magnetic resonance imaging, electrocardiographic imaging and epicardial mapping.

Improving risk stratification for infarction related sudden cardiac death by combining cardiac magnetic resonance imaging, electrocardiographic imaging and epicardial mapping. - Combining CMR, ECGI and epicardial mapping

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42753

Enrollment

630

Registered

2015-06-10

Start date

2015-11-09

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sudden cardiac death ventricular arrhythmias

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: CABG group: Patients scheduled for elective coronary artery bypass grafting. a.Patients without a history of myocardial infarction and ventricular tachyarrhythmias (No-infarct group). b. Patients with a previous myocardial infarction, but no history of ventricular tachyarrhythmias (No-VT group). c. Patients with a previous myocardial infarction and a history of ventricular tachyarrhythmias (VT group). ;ICD group: Patients with a prior myocardial infarction, scheduled for ICD implantation.

Exclusion criteria

Exclusion criteria: - Any contraindication for MRI. - Pregnant women, or women of child bearing potential and who are not on a reliable form of birth control

Design outcomes

Primary

Measure	Time frame
The primary study parameters include: - 3D electrical activation maps using epicardial mapping and ECGI. - The electrocardiographic characteristics (voltage amplitude, voltage duration, conduction velocity, fractionation) of the different tissue types (e.g. normal myocardium and scar). - The correlation between the electrocardiographic characteristics measured using epicardial mapping and ECGI. - 3D myocardial scar maps. - CMR characteristics of the different tissue types (e.g. normal myocardium and scar). - The correlation between the 3D electrical activation maps obtained using ECGI with the 3D CMR myocardial scar maps.	—

Measure

Time frame

The primary study parameters include: - 3D electrical activation maps using epicardial mapping and ECGI. - The electrocardiographic characteristics (voltage amplitude, voltage duration, conduction velocity, fractionation) of the different tissue types (e.g. normal myocardium and scar). - The correlation between the electrocardiographic characteristics measured using epicardial mapping and ECGI. - 3D myocardial scar maps. - CMR characteristics of the different tissue types (e.g. normal myocardium and scar). - The correlation between the 3D electrical activation maps obtained using ECGI with the 3D CMR myocardial scar maps.

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Secondary

Measure	Time frame
Secondary study parameters include e.g. individual evaluation of deaths and hospitalizations.	—

Countries

Netherlands

Outcome results