Applicability of cornea confocal microscopy in the diagnosis of small fiber neuropathy.

Applicability of cornea confocal microscopy in the diagnosis of small fiber neuropathy. - Cornea confocal microscopy in small fiber neuropathy.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42708

Enrollment

220

Registered

2015-10-12

Start date

2016-01-04

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

small fiber neuropathie

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy subjects (n

Exclusion criteria

Exclusion criteria: Healthy subjects (n=20) - Sensory symptoms in hands or feet or known with mono-/polyneuropathy. - Known illnesses that can cause neuropathy, like diabetes mellitus, renal failure, alcohol abuse, rheumatoid arthritis, SLE, sarcoidosis, and thyroid dysfunction. - History of diseases of the eye such as dry eyes, atopic keratoconjunctivitis, epithelial membrane basement dystrophies, cystic corneal disorders, which all affect corneal innervation. - Patients with chronic glycemic exposure since this is a strong risk factor for corneal subbasal nerve loss. - Use of medication (also in the past) known to possibly cause polyneuropathy.;Patients (n=200) - History of diseases of the eye (such as mentioned above);Participants are excluded from this study when they do not want to be informed about defects or accidental findings which could be found during the pre-screening of the ophthalmologist.

Design outcomes

Primary

Measure	Time frame
Corneal nerve fiber density (CNFD), branch density (CNBD), fiber length (CNFL), and the tortuosity coefficient (CNFT) will be determined in all participants.	—

Secondary

Measure	Time frame
-	—

Countries

Netherlands

Outcome results