DNA methylation profiling in blood of patients with cutaneous squamous cell carcinoma (cSCC) after organ transplantation

DNA methylation profiling in blood of patients with cutaneous squamous cell carcinoma (cSCC) after organ transplantation - Methylation profiling in post-transplant cSCC

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42690

Enrollment

Registered

2015-12-03

Start date

2016-01-05

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

orgaantransplantatie post-transplant cutaneous squamous cell carcinoma post-transplant skin cancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with (cases) compared to patients without (controls) cutaneous squamous cel carcinoma after their first organ transplantation

Exclusion criteria

Exclusion criteria: Previous transplantation (either solid or non-solid organ transplantation) History and presence of other malignancies (including skin malignancies before transplantation) Under 18 years of age

Design outcomes

Primary

Measure	Time frame
The primary study parameter is the difference in DNA methylation in CD3+ T cells between organ transplant recipients who developed cSCC and organ recipients who did not develop a malignancy.	—

Countries

Netherlands

Outcome results