multifocal motor neuropathy (MMN). This term is familiar to all MMN patients.
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of MMN according to internationally accepted criteria of the European Federation of Neurological Societies and Peripheral Nerve Society (EFNS/PNS criteria). 2. One median nerve (left or right) with any of the follwing abnormalities in the motor nerve conduction studies: a) conduction block in motor axons in the forearm segment, defined as segmental reduction of compound muscle action potential (CMAP) area of at least 30%; b) signs of demyelination: conduction velocity decrease up to 38 m/s or less and/or DML 5.3 ms or more and/or increase CMAP duration in the forearm of at least 30%; c) motor axon loss defined as decreased CMAP amplitude of 3 mV or less; 3. Age range 18-99 years old.
Exclusion criteria
Exclusion criteria: 1. Other causes for neuropathy than MMN, including carpal tunnel syndrome (CTS). 2. Use of medication affecting ion-channels in nerves.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Excitability-variables of motor and sensory axons of the median nerve at the wrist. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Outcome results
None listed