Het onderzoek wordt bij gezonde proefpersonen uitgevoerd. Uitkomsten uit deze lijn van onderzoek bieden nieuwe handvatten voor verklaringsmodellen en therapeutische interventies voor allergene aandoeningen waarbij een verandering in de histaminerespons optreedt. Not applicable
Conditions
Interventions
Conditioning takes place in the first 3 days of the acquisition phase, i.e. in
the experimental, open label and conditioned not evoked groups, Histamine-1
receptor responsiveness to histamine will b
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Between 18 and 35 years old; healthy, or when allergic, no current allergic rhinitis or allergic conjunctivitis symptoms
Exclusion criteria
Exclusion criteria: Somatic and/or psychiatric conditions (e.g. asthma), recent infection, recent use of medication (excluding oral contraceptives), recent vaccinations, current or recent (within past 3 months) allergic rhinitis or allergic conjunctivitis symptoms, any allergic condition other than allergic rhinitis or conjunctivitis, sensitivity to any substance used in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is self-reported mean itch during histamine iontophoresis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include the immediate inflammatory response (e.g., cytokines), bronchodilation, wheal size, flare response, skin temperature, and self-reported skin condition, and scratching behaviour following histamine iontophoresis, skin conductance and heart rate, and self-reported wellbeing. The possible influence of genetic variants (e.g. the 5HTTLPR-genotype) and of psychological factors on conditioning will be explored. | — |
Countries
Netherlands
Outcome results
None listed