virale infectieziekten asymptomatic pneumococcal nasopharyngeal colonisation pneumococcal carriage
Conditions
Interventions
None listed
Sponsors
RIVM
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: The children have to be of normal health (same health criteria apply as used in well-baby clinics when a child receives a vaccination, e.g. also children with small increases in temperature or cold are seen as children with normal health, fever >38.5°C in the last two days is not considered as normal health). The parents have to be willing and able to participate in the trial according to procedure. The child is 24-months-old (± 4 weeks) or 46-months-old (43-48-months) The child has been vaccinated according to the Dutch NIP Presence of a signed informed consent (the parents/legally representatives have given written informed consent after receiving oral and written information). Parents of 24-month-old children are included when their child fulfils the inclusion criteria.
Exclusion criteria
Exclusion criteria: For children: Previous vaccinations with PCV using a vaccine and schedule that differs from the Dutch NIP of that age group. Medical conditions that will severely affect immunological responses to vaccinations or NP carriage rates (certain chromosomal abnormalities or craniofacial abnormalities (like Trisomy 21 or schisis), known or suspected immunodeficiency disease or other medical conditions). Coagulation disorder/anticoagulant medication.;For parents: Medical conditions that will severely affect immunological responses to vaccinations or NP carriage rates (certain chromosomal abnormalities or craniofacial abnormalities (like Trisomy 21 or schisis), known or suspected immunodeficiency disease or other medical conditions). Coagulation disorder/anticoagulant medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total pneumococcal vaccine and non-vaccine serotypes | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequencies of individual pneumococcal serotypes, respiratory viral and non-pneumococcal bacterial carriage, (functional) antibody titers, B and T cell immunity, age related immune markers, microbiome, antibiotic non-susceptibility of pathogens. | — |
Countries
Netherlands
Outcome results
None listed