On the origin of cerebral small vessel disease

On the origin of cerebral small vessel disease - On the origin of cerebral small vessel disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42650

Enrollment

Registered

2015-10-06

Start date

2016-03-11

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebral small vessel disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Participants will be recruited from our ongoing RUNDMC study. The current proposal can be seen as an extension of the RUNDMC Study. Eligibility criteria for participation with the RUNDMC study included the presence of cerebral small vessel disease on neuroimaging (made because of symptoms of small vessel disease), age 50-85 years. For the current extension the following inclusion criteria will be added:;- Above RUNDMC average progression of cerebral small vessel disease as assessed on sequential MRI scanning in 2006 and 2012. - Have risk factors of progression - Hypertension - IADL > 6 (functionally independent) - Being able to visit the research centre on a monthly basis

Exclusion criteria

Exclusion criteria: - Atrial fibrillation - carotid artery stenosis > 50% - Dementia - Mild cognitive impairment - Parkinsonism - Diabetes

Design outcomes

Primary

Measure	Time frame
incident small vessel disease	—

Secondary

Measure	Time frame
progression of small vessel disease cognitive decline motor decline	—

Countries

Netherlands

Outcome results