developmental delay
Conditions
Interventions
None listed
Sponsors
Maxima Medisch Centrum
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, mothers who participated in the HAPPY study and their children that were born during the HAPPY study must meet the following criteria: • 200 mothers with recurrent depressive symptoms during pregnancy and their (200) children. Within HAPPY there were 3 assessments of depression during pregnancy, and five during postpartum. Recurrent depression is defined as an EDS score above cut-off at three consecutive assessment during pregnancy and/or at least three times an EDS above the cut-off during the 12 months postpartum follow-up. • 150 mothers with sub-optimal thyroid function (elevated TPO-Ab titres; 8.8% of 1353 women = 119) and /or sub-clinical hypothyroidism (TSH > 90th percentile = 135 women) and / or hypothyroxinemia. (FT4
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Hospitalization in a psychiatric hospital in the previous 12 months - A known serious psychiatric disease diagnosis (bi-polar disorder, psychotic depression, personality disorder) at the time of the home visit - Severe depression with suicidal ideation during home visit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will compare developmental scores of children of mothers with and without maternal thyroid dysfunction during gestation and of mothers with and of mothers with and without depression during pregnancy and the post-partum. Moreover, we will compare ultrasound data at 20 weeks gestation (cerebellum size, ventricle size and bi-parietal diameter) in the thyroid group and the healthy controls, possibly correlating thyroid function to CNS parameters. | — |
Countries
Netherlands
Outcome results
None listed