The effects of an active versus an inactive lifestyle on the renal function during exercise and dehydration

The effects of an active versus an inactive lifestyle on the renal function during exercise and dehydration - Renal function during exercise and dehydration

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42643

Enrollment

Registered

2015-05-27

Start date

2015-06-02

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inspannings gerelateerde gezondheidsrisico's Dehydration

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy Male (18-30 years) Active group: activity-score >=9400. Inactive group: activity-score

Exclusion criteria

Exclusion criteria: - History of kidney disease - Baseline estimated glomerular filtration rate

Design outcomes

Primary

Measure	Time frame
The primary outcome parameters of this study are the estimated glomerular filtration rate, the plasma copeptide concentration and the plasma renin activity.	—

Secondary

Measure	Time frame
Secondary study parameters/endpoints (if applicable) • Serum and urine creatinine concentration (as a measure for renal clearance) • Plasma and urine osmolarity (as a measure for fluid balance and urine concentrating ability) • Plasma and urine sodium concentration (as a measure for the fluid balance) • Urine Aquaporine-2 (AQP2) concentration (as a measure for urine concentrating ability) • Hematocrit en Hemoglobine (as markers for dehydration, which can be used to calculate plasma volume changes) Other study parameters (if applicable) • Hart rate (to determine the exercise intensity during the sub-maximal exercise) • Rating of Perceived Exertion (BORG-score). • Thermal Sensation Score. • Plasma en urine succinate concentration (as a measure for renal stress/damage) • Plasma en urine lactate concentration (as a measure for renal stress/damage) • Urine glucose concentration (as a measure for renal stress/temporary proximal tubulus damage) • Urine albumine concentration (as a measure for renal stress/damage) • Urine Kidney Injury Molecule-1 (KIM-1) concentration (as a measure for renal stress/damage) • Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) concentration (as a measure for renal stress/temporary distal tubulus damage) • Urine IgG concentration (as a measure for renal stress/temporary glomerular damage)	—

Measure

Time frame

Secondary study parameters/endpoints (if applicable) • Serum and urine creatinine concentration (as a measure for renal clearance) • Plasma and urine osmolarity (as a measure for fluid balance and urine concentrating ability) • Plasma and urine sodium concentration (as a measure for the fluid balance) • Urine Aquaporine-2 (AQP2) concentration (as a measure for urine concentrating ability) • Hematocrit en Hemoglobine (as markers for dehydration, which can be used to calculate plasma volume changes) Other study parameters (if applicable) • Hart rate (to determine the exercise intensity during the sub-maximal exercise) • Rating of Perceived Exertion (BORG-score). • Thermal Sensation Score. • Plasma en urine succinate concentration (as a measure for renal stress/damage) • Plasma en urine lactate concentration (as a measure for renal stress/damage) • Urine glucose concentration (as a measure for renal stress/temporary proximal tubulus damage) • Urine albumine concentration (as a measure for renal stress/damage) • Urine Kidney Injury Molecule-1 (KIM-1) concentration (as a measure for renal stress/damage) • Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) concentration (as a measure for renal stress/temporary distal tubulus damage) • Urine IgG concentration (as a measure for renal stress/temporary glomerular damage)

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Countries

Netherlands

Outcome results