Bloating dyspepsia
Conditions
Interventions
Drinking 500 mL beer (1x training, 1x test) and a carbonated softdrink (1x) in
20 min.
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Age: 18-40 years -BMI: 18.5 - 25.0 kg/m2 -Healthy (as judged by the participant) -On average consuming more than 1 unit of beer per month but less than 13 units per week. -On average consuming more than 1 unit of soft drink per month but less than 13 units per week. -Willing to be informed about incidental findings of pathology and approving of reporting this to their general physician.
Exclusion criteria
Exclusion criteria: -Drug use or medical conditions which may interfere with normal functioning of the digestive tract. -Drug use or medical conditions which may interfere with normal functioning of the circulatory system -Drug use or medical conditions which may lead to unreliable fMRI results (including, but not limited to neurological conditions) -Reported unexplained weight loss or weight gain of > 5 kg in the month prior to pre-study screening -For women: having the intention to become pregnant, pregnancy during the last 6 months or lactating - Smoking on average more than one cigarette/cigar a day -Having a contra-indication to MRI scanning including, but not limited to, metal in the body and claustrofobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Gastric measures (MRI): Gastric volume, air and liquid gastric compartments. 2) Subjective ratings of fullness and bloating. 3) Changes in regional brain activity in brain regions associated with visceral perception and processing, as assessed with perfusion fMRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective feelings of appetite, thirst and nausea. | — |
Countries
Netherlands
Outcome results
None listed