chronische pijn chronic pain pain
Conditions
Interventions
1. inhalation of cannabis
2. questionnaires (HADS, Bond & Lader, Bowdle, POMS)
3. Blood sampling
4. pain testing
5. Cornea photo (Cornea Confocal Microscopy)
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Twenty pain patients diagnosed with fibromyalgia will be included if they have a pain score p(on a scale from 0
Exclusion criteria
Exclusion criteria: i) Unable to give written informed consent; (ii) medical disease such as pulmonary, renal, liver, cardiac, gastro-intestinal, vascular disease; (iii) allergy to study medication; (iv) use of strong opioids; (v) use of benzodiazepines; (vi) history of illicit drug use (incl. cannabis-related products) or alcohol abuse; (vii) (family) history of psychosis; (viii) epilepsy; (ix) raised intracranial pressure;(x) pregnancy and/or lactation; (xi) the presence of pain syndromes other than fibromyalgia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main end-points: PK data, spontaneous and experimental pain relief. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary end-points: Blood pressure, cardiac output, temperature, mental state (drug high, internal perception, external perception, depression, anxiety, arousal, positive mood, alertness, contentment, calmness), psychomimetic side effects. | — |
Countries
Netherlands
Outcome results
None listed