Energy metabolism of working muscles in patients after burn injury

Energy metabolism of working muscles in patients after burn injury - MetWork

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42597

Enrollment

Registered

2015-10-08

Start date

2016-03-18

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

burn wounds

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients aged 18-65 years, admitted to the Martini Hospital Burn Center with burns covering 15% or more of total body surface area (TBSA).

Exclusion criteria

Exclusion criteria: - only facial burns - contraindications for MRI studies - inability to perform bicycle exercise - contra-indications for high intensity exercise testing - known coronary artery disease, positive history for angina pectoris, or changes on ECG suggestive of previous ischaemia without a negative stress test - intercurrent illness which may influence exercise tolerance (anaemia, musculoskeletal injury, or other undiagnosed illness under investigation) - pre-existing insulin-dependent diabetes mellitus - pregnancy or current breastfeeding, or females not taking the oral contraceptive pill - any other cause which in the opinion of the investigators, may affect the volunteers ability to participate in the study - insufficient proficiency in Dutch or English to the extent that clear communication is not possible - loss of, or an inability to give informed consent

Design outcomes

Primary

Measure	Time frame
In vivo intramuscular steady-state levels of inorganic phosphate (Pi), phoshocreatine (PCr), and pH at rest versus (prolonged) exercise, and the dynamics of Pi, PCr and pH recovery following exercise.	—

Secondary

Measure	Time frame
• Body composition - body height (m) - body weight (kg) - waist circumference (cm) • Muscle strength - maximal isokinetic leg muscle strength (Newton), including Visual Analogue Scale (VAS) score for pain assessment during the test - grip strength (Newton) • Aerobic exercise capacity - VO2max, FATMAX, peak work rate, peak heart rate, and percentage heart rate recovery after 1 and 2 minutes - subjective fatigue and muscle ache score after CPET (scale 0-10) • Prolonged exercise - completion of 35 min upright bicycling bout at FATMAX (yes/no; if no, #minutes) - completion of 10 min supine bicycling bout at FATMAX in scanner (yes/no; if no, #minutes) - subjective fatigue and muscle ache score after each exercise bout (scale 0-10) • Activity and fatigue - Habitual Physical Activity Questionnaire - Brief Fatigue Inventory	—

Measure

Time frame

• Body composition - body height (m) - body weight (kg) - waist circumference (cm) • Muscle strength - maximal isokinetic leg muscle strength (Newton), including Visual Analogue Scale (VAS) score for pain assessment during the test - grip strength (Newton) • Aerobic exercise capacity - VO2max, FATMAX, peak work rate, peak heart rate, and percentage heart rate recovery after 1 and 2 minutes - subjective fatigue and muscle ache score after CPET (scale 0-10) • Prolonged exercise - completion of 35 min upright bicycling bout at FATMAX (yes/no; if no, #minutes) - completion of 10 min supine bicycling bout at FATMAX in scanner (yes/no; if no, #minutes) - subjective fatigue and muscle ache score after each exercise bout (scale 0-10) • Activity and fatigue - Habitual Physical Activity Questionnaire - Brief Fatigue Inventory

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Countries

Netherlands

Outcome results