Diagnostic value of DECT scan compared to diagnostic needle aspiration DEteCTing gout, with or without a needle

Diagnostic value of DECT scan compared to diagnostic needle aspiration DEteCTing gout, with or without a needle - DEteCTing gout

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42591

Enrollment

100

Registered

2015-12-29

Start date

2016-04-25

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gout

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age > 18 years Mono or oligo arthritis (2-3 swollen joints) Indication for diagnostic aspiration of an inflamed joint in which gout is one of the possibilities

Exclusion criteria

Exclusion criteria: Polyarthritis (>=4 swollen joint); Chrystal proven gout in history Patient is on uric acid lowering therapy (Allopurinol, Benzbromaron, Febuxostat) Hip arthritis Metal or prosthesis of the inflamed joint Highly suspicion of infectious arthritis Pregnancy Contra indication of joint aspiration (skin infection, hemophilia) No informed consent

Design outcomes

Primary

Measure	Time frame
The sensitivity and specificity (95% CI) of DECT scanning for the detection of MSU deposition will be calculated. The area under receiver operating characteristic curve (AUC-ROC) will be employed to evaluate the screening method*s performance.	—

Secondary

Measure	Time frame
Identify the clinical features and laboratory variables that affect the primary outcome measure of positive DECT scan for lesions suggestive of uric acid deposition in patients with acute mono or oligo arthritis. Establish the additive value of ultrasound guided joint aspiration in patients in whom the first aspirate demonstrated no microscopic MSU and /or no synovial fluid Establish the additive value of ultrasound guided joint aspiration of DECT lesions suggestive of gout in patients in whom the earlier aspirate(s) demonstrated no microscopic MSU and /or no synovial fluid. Cost effectiveness analysis of different diagnostic strategies. Patient satisfaction: What does the patient experience as the most patient-friendly way of diagnosing gout: DECT scan, ultrasound-guided joint aspiration or blind aspiration?	—

Measure

Time frame

Identify the clinical features and laboratory variables that affect the primary outcome measure of positive DECT scan for lesions suggestive of uric acid deposition in patients with acute mono or oligo arthritis. Establish the additive value of ultrasound guided joint aspiration in patients in whom the first aspirate demonstrated no microscopic MSU and /or no synovial fluid Establish the additive value of ultrasound guided joint aspiration of DECT lesions suggestive of gout in patients in whom the earlier aspirate(s) demonstrated no microscopic MSU and /or no synovial fluid. Cost effectiveness analysis of different diagnostic strategies. Patient satisfaction: What does the patient experience as the most patient-friendly way of diagnosing gout: DECT scan, ultrasound-guided joint aspiration or blind aspiration?

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Countries

Netherlands

Outcome results