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In Vitro Characterization and Enhancement of HIV-Specific CD8+ T Cells

In Vitro Characterization and Enhancement of HIV-Specific CD8+ T Cells - CD8+ T cells in HIV

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON42584
Enrollment
396
Registered
2015-09-08
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

AIDS HIV infection

Interventions

None listed

Sponsors

Erasmus MC, Universitair Medisch Centrum Rotterdam
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age >18 years Confirmed HIV-1 infection Treatment or viral loads that fit into one of the study groups

Exclusion criteria

Exclusion criteria: Inability to donate 50 ml of blood Pregnancy or breastfeeding Major comorbidities

Design outcomes

Primary

MeasureTime frame
This is a discovery study aiming to study exhaustion in HIV-specific CD8+ T cells and how these functional defects can be modified by epigenetic inhibitors. The main study parameters are a) phenotypic and functional characterization of HIV- and CMV-specific CD8+ T cells from HIV-infected individuals; b) Increase of function and reverse of exhaustion phenotype by epigenetic inhibitors; c) Expression pattern of select post-transcriptional modifiers in HIV- and CMV-specific CD8+ T cells from HIV-infected individuals.—

Secondary

MeasureTime frame
Non applicable—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)