Effects of collagen peptide supplementation on knee JOINT discomfort during and after repetitive low-INtensity exercise

Effects of collagen peptide supplementation on knee JOINT discomfort during and after repetitive low-INtensity exercise - JOIN(T)-IN

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON42581

Enrollment

200

Registered

2016-02-26

Start date

2016-04-13

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gewrichtsaandoeningen joint discomfort Knee discomfort

Interventions

Daily supplementation of collagen peptide (10g) or placebo (maltodextrin

10g), additionally to their habitual breakfast for a period of 12 weeks. All supplements will be provided as flavored powder drink products that can be dissolved in water.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: o Registration for the Nijmegen Four Days Marches 2016 o Self-reported activity-related knee discomfort (VAS score >=1) o Between 50 and 75 years of age o Willingness to provide written consent after proper information about the study objectives and procedures.

Exclusion criteria

Exclusion criteria: o A known systemic joint or muscle disease o Individuals that follow a low protein diet for medical reasons due to known kidney disease. o Disease influencing the uptake of protein (i.e. inflammatory bowel disease, Crohn*s disease) o Vegetarian diet o Diabetes mellitus (type 1 and type 2) o Recent knee surgery (

Design outcomes

Primary

Measure	Time frame
The primary outcome parameter is the difference in activity-related knee discomfort expressed by the VAS-score at baseline and after the intervention period/during the Nijmegen four-day marches. Furthermore, questionnaires, handgrip strength, muscle contraction characteristics, inflammatory markers and bone and joint markers will be assessed as secondary outcome parameters.	—

Secondary

Measure	Time frame
Secondary study parameters/endpoints (if applicable) o (Changes in) activity-related knee discomfort expressed by and the KOOS score Lysholm score o Handgrip strength o Maximal voluntary strength of the quadriceps muscle o Fatigue-index and force-frequency relationship of the quadriceps muscle o Inflammatory markers (IL-6, IL-1beta, TNF-alpha, MCP-1, hsCRP) o Bone and joint markers (PINP, CTX, osteocalcin, CP2, CTXII) Other study parameters (if applicable) o Subject characteristics (anthropometrics) o Protein intake (24h recall) o Physical activity (SQUASH) and exercise training (diary) o Liver and kidney health urine/blood parameters	—

Measure

Time frame

Secondary study parameters/endpoints (if applicable) o (Changes in) activity-related knee discomfort expressed by and the KOOS score Lysholm score o Handgrip strength o Maximal voluntary strength of the quadriceps muscle o Fatigue-index and force-frequency relationship of the quadriceps muscle o Inflammatory markers (IL-6, IL-1beta, TNF-alpha, MCP-1, hsCRP) o Bone and joint markers (PINP, CTX, osteocalcin, CP2, CTXII) Other study parameters (if applicable) o Subject characteristics (anthropometrics) o Protein intake (24h recall) o Physical activity (SQUASH) and exercise training (diary) o Liver and kidney health urine/blood parameters

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)