coronary artery disease ischemic heart disease
Conditions
Interventions
None listed
Sponsors
NewYork-Presbyterian Hospital and Weill Cornell Medical College
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age *18 years Scheduled to undergo clinically-indicated non-emergent invasive coronary angiography
Exclusion criteria
Exclusion criteria: 1) Known CAD (myocardial infarction [MI], percutaneous coronary interventions [PCIs], coronary artery bypass graft [CABG],) 2) Hemodynamic instability 3) Inability to provide written informed consent 4) Concomitant participation in another clinical trial in which subject is subject to investigational drug or device 5) Pregnant state 6) Absolute contraindication to iodinated contrast due to prior near-fatal anaphylactoid reaction (laryngospasm, bronchospasm, cardiorespiratory collapse, or equivalent) 7) Serum creatinine *1.7 mg/dl or Glomerular Filtration Rate 40 kg/m2 13)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the diagnostic accuracy of an integrated stenosis-APC-FFRCT metric by CT, as compared to perfusion or perfusion-MBF stress imaging testing for vessel territory-specific ischemia as determined by FFR (gold standard). | — |
Secondary
| Measure | Time frame |
|---|---|
| - To compare the accuracy of the individual components of APCs or FFRCT to MPI vessel-specific perfusion deficits or reduced MBF against ischemia by FFR. - To determine the accuracy of FFRCT *virtual stenting* to post-PCI FFR value of >0.80 and determine the correlation between the FFRCT *virtual stenting* to post-PCI FFR. | — |
Countries
Netherlands
Outcome results
None listed