The role of perivascular adipose tissue in the regulation of insulin sensitivity through muscle microvascular recruitment in non-obese and obese individuals

The role of perivascular adipose tissue in the regulation of insulin sensitivity through muscle microvascular recruitment in non-obese and obese individuals - PVAT, metabolism and vascular health

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42523

Enrollment

Registered

2015-09-22

Start date

2016-05-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Male - Caucasian - age 18-60 years - BMI is *23 and

Exclusion criteria

Exclusion criteria: - Documented CVD - Diabetes mellitus - Stage 2 hypertension (resting blood pressure >160/100 mmHg) - History of severe inflammatory conditions in the past 15 years - Recent infections - recent history ( 4 U/day, more than 3 days in a row - Use of medication potentially affection insulin sensitivity, microvascular function or inflammation - Use of anticoagulants (types Warfarin and Coumadin derivatives) that can increase the risk of bleeding during the muscle biopsy (exception is made for aspirin). - Malignancies (except those of the skin), renal and hepatic diseases. - Smoking - Recent (10%) changes in body weight.

Design outcomes

Primary

Measure	Time frame
Functional and inflammatory properties of PVAT will be quantified and correlations with whole-body and microvascular insulin sensitivity will be analysed. Vasoreactivity of skeletal muscle arterioles with and without perivascular adipose tissue will be studied. We will measure markers of low-grade systemic inflammation and adipocytokines (IL-6, IL-8, leptin, TNF-*, MCP-1, adiponectin, resistin and PAI-1, fibrinogen) . Pearson's and Spearman correlation analyses will be conducted as appropriate to select the variable that is best correlating with insulin sensitivity. step-wise multivariate linear regressions will be performed to examine the relations between two variables, controlling for anthropometry and systemic inflammation, and standardized betas (B) are reported.	—

Measure

Time frame

Functional and inflammatory properties of PVAT will be quantified and correlations with whole-body and microvascular insulin sensitivity will be analysed. Vasoreactivity of skeletal muscle arterioles with and without perivascular adipose tissue will be studied. We will measure markers of low-grade systemic inflammation and adipocytokines (IL-6, IL-8, leptin, TNF-*, MCP-1, adiponectin, resistin and PAI-1, fibrinogen) . Pearson's and Spearman correlation analyses will be conducted as appropriate to select the variable that is best correlating with insulin sensitivity. step-wise multivariate linear regressions will be performed to examine the relations between two variables, controlling for anthropometry and systemic inflammation, and standardized betas (B) are reported.

—

Secondary

Measure	Time frame
Pearson's and Spearman correlation analyses will be conducted as appropriate. Correlations of microvascular recruitment in the heart will be correlated in a regression analysis using PVAT properties, anthropometric properties and inflammatory properties.	—

Countries

Netherlands

Outcome results