Inhibition during unilateral and bilateral contractions in young and older adults

Inhibition during unilateral and bilateral contractions in young and older adults - Inhibition during bilateral contractions in older adults

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON42517

Enrollment

Registered

2015-12-01

Start date

2016-03-30

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

fundamenteel onderzoek met gezonde proefpersonen not applicable

Interventions

Subjects produce force with one and/or both index finger abductors. During the contractions we stimulate the motor cortex with transcranial magnetic stimulation (TMS).

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: righthandedness age: 18-35 or 45 years and older

Exclusion criteria

Exclusion criteria: neurological or muscle disorders epilepsy migraine pregnancy

Design outcomes

Primary

Measure	Time frame
We will determine the amplitude of the motor evoked potential (MEP). The MEP is expressed as a percentage of the electrically evoked muscle response (M-max). The MEP is a measure of cortico-spinal excitability. We expect the MEP to be modulated by performing unilateral or bilateral contractions. We also expect that the modulation will be age-related. MEP amplitude is also the outcome of different inhibitions protocols, expressed as an percentage of the baseline value.	—

Measure

Time frame

We will determine the amplitude of the motor evoked potential (MEP). The MEP is expressed as a percentage of the electrically evoked muscle response (M-max). The MEP is a measure of cortico-spinal excitability. We expect the MEP to be modulated by performing unilateral or bilateral contractions. We also expect that the modulation will be age-related. MEP amplitude is also the outcome of different inhibitions protocols, expressed as an percentage of the baseline value.

—

Secondary

Measure	Time frame
The inhibition measures of different TMS protocols (SICI, IHI, SP) en the amount of associated activity. These measures are linked to the primary parameters (MEP amplitude).	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)