Arterial spin labelling for the assessment of cerebral autoregulation - a proof of principle

Arterial spin labelling for the assessment of cerebral autoregulation - a proof of principle - ASL for cerebral autoregulation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42505

Enrollment

Registered

2015-10-07

Start date

2015-12-21

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's Disease dementia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Written informed consent - Age 18-40 or age 55-75

Exclusion criteria

Exclusion criteria: -Subjects who cannot have an MRI, e.g. due to claustrophobia, metal in upper body, have an implant or who suffer from epilepsy. oIncreased risk on coronary spasms oRecent (

Design outcomes

Primary

Measure	Time frame
• Relative cerebral blood flow changes over time (every 5s) • Relative blood pressure changes over time (every 5s)	—

Secondary

Measure	Time frame
Feasibility: o # of deviations from protocol o # of motion artifacts in ASL images o # of motion artifacts in CareTaker Validity o Oscillations in mean cerebral blood flow - rASL - NIRS o Oscillations in MAP - CareTaker - Finapres To assess the magnitude of changes that can be detected o Variation due to physiological changes o Variation due to measurement noise	—

Countries

Netherlands

Outcome results