cognitieve stoornissen Parkinson's Disease-related mild cognitive impairment (PD-MCI)
Conditions
Interventions
Bipolar tDCS will be administered using two saline-soaked surface sponge
electrodes (area 7 x 5 cm2) and delivered by a battery-driven, constant-current
stimulator.
For atDCS, the anode will be pla
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) Clinical diagnosis of PD according to the UK PD Brain Bank criteria60 2) PD-related mild cognitive impairment (PD-MCI) 3) If applicable, stable maintenance of their medication, including dopaminergic treatment, for at least 30 days prior to enrollment and throughout the study.;For the collection on data on instrumental activities of daily living 4) Presence of an informal informant 5) Ability of the informant to complete the questionnaire.
Exclusion criteria
Exclusion criteria: 1) Insufficient mastery of the Dutch language 2) Inability to understand test instructions in Dutch language 3) Any contra indications to tDCS like metallic implants (pacemaker etc.) 4) History of seizures 5) Substance abuse 6) Dementia 7) Major head trauma 8) Bipolar or psychiatric disorder 9) Signs of depression (Hospital Anxiety and Depression Scale, sub score D >7)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy of atDCS in the improvement of executive functioning in PD-MCI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Network connectivity as a predictor and monitor of treatment response Instrumental activities of daily living Motor symptoms Pain perception Health-related quality of life Mood | — |
Countries
Netherlands
Outcome results
None listed