Assess the mtDNA mutation load in mesoangioblasts of mtDNA mutation carriers

Assess the mtDNA mutation load in mesoangioblasts of mtDNA mutation carriers - mtDNA mutation load analysis MABs

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42480

Enrollment

Registered

2016-01-14

Start date

2016-02-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mitochondrial myopathy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Adult carriers of a mtDNA mutation in blood >10%

Exclusion criteria

Exclusion criteria: Significant concurrent illness Pregnant or lactating women Psychiatric or other disorders likely to impact on informed consent Patients unable and/or unwilling to comply with treatment and study instructions Any other factor that in the opinion of the investigator excludes the patient from the study

Design outcomes

Primary

Measure	Time frame
mtDNA mutation load in single MABs and skeletal muscle	—

Secondary

Measure	Time frame
mtDNA copy number in MABs OXPHOS capacity in MABs Proliferation capacity MABs Myogenic differentiation capacity of MABs	—

Countries

Netherlands

Outcome results