Assessment of Knee Cartilage Quality at 7T MRI with Glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST)

Assessment of Knee Cartilage Quality at 7T MRI with Glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST) - QUICK, QUantitative Imaging of Cartilage in the Knee

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42475

Enrollment

Registered

2016-01-13

Start date

2016-03-08

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cartilage degeneration Osteoarthritis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients who are planned to undergo a total knee arthroplasty because of severe cartilage damage or patients who are planned to undergo an arthroscopy because of suspected cartilage damage.

Exclusion criteria

Exclusion criteria: Patients with previous knee surgery. Patients with other prostheses or metal objects/hardware. Patients with contra-indications to MRI scanning according to hospitals 7T MRI screening guideline of the UMC Utrecht

Design outcomes

Primary

Measure	Time frame
Validation of the gagCEST protocol with histology as golden standard Detection of (or a reproducible gradation of) the cartilage defects based on the gagCEST MRI measurements for (early) diagnosis and monitoring of osteoarthritis.	—

Secondary

Measure	Time frame
Relate the cartilage thickness on the clinically relevant morphological MRI with the MTR asymmetry spectrum based on the gagCEST MRI.	—

Countries

Netherlands

Outcome results