Endothelial activation during cooling and recovery in patients with primary and secondary Raynaud*s phenomenon: a feasibility/pilot study

Endothelial activation during cooling and recovery in patients with primary and secondary Raynaud*s phenomenon: a feasibility/pilot study - Endothelial activation in Raynaud

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42460

Enrollment

Registered

2015-07-23

Start date

2015-09-10

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Scleroderma Systemic Sclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -18 years or older -Written informed consent -Of sound mind and judgement;Subjects from group 2, 3 and 4 must meet the following additional criteria: -Raynaud*s phenomenon (RP), presenting with typical signs or symptoms, objectively documented with cooling and recovery photoplethysmogram (PPG);Subjects from group 3 and 4 must meet the following additional criteria: -Systemic Sclerosis, determined by 2013 ACR/EULAR criteria;Subjects from group 4 must meet the following additional criteria: -Previously objectively documented with heart catheterization defined as a resting mean pulmonary artery pressure (mPAP) >= 25 mm Hg

Exclusion criteria

Exclusion criteria: -Inability to perform a venous punction -Inabiilty to perform ppg

Design outcomes

Primary

Measure	Time frame
The main study parameters are the blood and plasma levels of several parameters, i.e. venous lactate, bicarbonate, pH, sVCAM-1, sICAM-1, soluble E-selectin, PDGF-B, TGF-β, EGR-1. Also, peripheral blood mononuclear cells will be isolated for immunoblotting.	—

Countries

Netherlands

Outcome results