Metformin and Core Temperature in Obese and lean Males (McTOM)

Metformin and Core Temperature in Obese and lean Males (McTOM) - McTOM

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42453

Enrollment

Registered

2015-07-22

Start date

2015-10-15

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Energy disposal energy dissipating organ

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Male - Caucasian origin - Subjects should be able and willing to give informed consent - > 50 years old - BMI> 28 kg/m2 or BMI

Exclusion criteria

Exclusion criteria: - Renal failure (GFR

Design outcomes

Primary

Measure	Time frame
Difference in 18F-FDG uptake as registered by 18F-FDG PET-CT before and after 7 days of daily metformin use	—

Secondary

Measure	Time frame
- Difference in core body temperature before and after metformin use and the correlation with 18F-FDG uptake - Difference in energy expenditure before and after metformin use and the correlation with 18F-FDG uptake. - Correlation between difference in core temperature and respectively 18F-FDG uptake and energy expenditure, before, after 7 days of daily metformin use. - Difference in lactate, before and after the use of metformin and the correlation between lactate and respectively 18F-FDG uptake, core body temperature and energy expenditure.	—

Measure

Time frame

- Difference in core body temperature before and after metformin use and the correlation with 18F-FDG uptake - Difference in energy expenditure before and after metformin use and the correlation with 18F-FDG uptake. - Correlation between difference in core temperature and respectively 18F-FDG uptake and energy expenditure, before, after 7 days of daily metformin use. - Difference in lactate, before and after the use of metformin and the correlation between lactate and respectively 18F-FDG uptake, core body temperature and energy expenditure.

—

Countries

Netherlands

Outcome results