nephrosclerosis
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 5.1 Population Group 1: 12 healthy volunteers aged * 18 years Group 2a: 12 living kidney donors Group 2b: 12 kidney tranplant recipients;5.2 Inclusion criteria In order to be eligible to participate in this study, a subject must meet all of the following criteria: - General inclusion criteria * age *18 years * able to give informed consent
Exclusion criteria
Exclusion criteria: 5.3 Exclusion criteria;o General exclusion criteria (for volunteers and patients): * not willing to be informed about unexpected findings during the study * (possible) pregnancy or lactation * known or suspected diseases or conditions that could interfere with the study * Contra-indications to MRI (for volunteers and patients), based on current practices, including: * Claustrophobia * metal implants, devices etc.: endoprosthesis, pacemaker, birth control device (IUD), neurostimulator, insulin pump, intra-ocular metal particles, metal heart valve, cochlear implant;o Group specific exclusion criteria: Group 1 * use of any prescribed medication (excl. contraceptives) and home use of NSAID*s during the study * body mass index >30 * diagnosed hypertension or hypertension (>140/90mmHg) upon screening * smoking;Group 2a * matching kidney transplant recipient not willing to participate;Groep 2b * matching kidney transplant donor not willing to participate * absolute contraindications for short-term blood pressure pertubations
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Change in intra individual changes in renal desoxygenation, metabolism and renal blood flow. | — |
Primary
| Measure | Time frame |
|---|---|
| Intra individual changes in renal desoxygenation, metabolism and renal blood flow. | — |
Countries
Netherlands
Outcome results
None listed