arrhythmia atrial fibrillation
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Paroxysmal, persistent or longstanding persistent AF - Undergoing electrical or pharmacological cardioversion - Adequate oral anticoagulation according to guidelines with oral anticoagulants or NOACs OR - Atrial thrombosis ruled out by TEE according to guidelines - Age > 18 years. - Legally competent and willing and able to sign informed consent
Exclusion criteria
Exclusion criteria: we refer to protocol p. 12-13 for a complete list of exlusion criteria - INR 22 - Unable or unwilling to comply with study procedures - Permanent AF accepted by the patient and physician - Presence of severe mitral regurgitation or stenosis or history of valvular surgery - AF with a generally reversible cause (cardiac surgery, pulmonary embolism, hyperthyroidism) - Chronic inflammatory disease or evidence of active infection (as evidenced by increased white blood cell count, elevated CRP level or fever > 38,5 °C) - NYHA class IV heart failure symptoms or left ventricular ejection fraction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters are the changes of biomarkerlevels overtime during the follow-up period. These will be associated with the incidence of recurrent AF after 6-8 months follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| Additional study parameters on the process of atrial remodeling and clinical data will be collected and include: - 2 echocardiographies during the follow-up visits as a non-invasive marker of atrial mechanical or structural remodeling - clinical data on cardiac history - in depth ECG analysis | — |
Countries
Netherlands
Outcome results
None listed