Contrast enhanced ultrasound to measure cerebral blood flow

Contrast enhanced ultrasound to measure cerebral blood flow - Contrast enhanced ultrasound to measure cerebral blood flow

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42396

Enrollment

Registered

2015-04-23

Start date

2015-06-24

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute brain injury acute cerebral ischemia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy men or women of 18-35 years old

Exclusion criteria

Exclusion criteria: Hypersensitivity to the active substance(s) or to any of the excipients in SonoVue Right-to-left shunt cardiac shunt Severe pulmonary hypertension (pulmonary artery pressure >90 mmHg) Uncontrolled systemic hypertension Pregnancy Lactation Participation in another clinical trial within 3 months prior to the experimental day. History, signs, or symptoms of cardiovascular disease or pulmonary disease History, signs or symptoms of neurological disease History of hyperventilation

Design outcomes

Primary

Measure	Time frame
Main study parameter is the reproducibility of the CEUS bolus kinetics and the flash-replenishment method. A difference between the measurements of more than 10% is considered to imply poor reproducibility. As a control, the reproducibility of measurement of the flow velocity in the ipsilateral middle cerebral artery will be assessed. .	—

Secondary

Measure	Time frame
Secondary study parameters are 1) Correlation between the bolus kinetics approach and the flash-replenishment method and 2) Comparison of the CEUS bolus technique with transcranial Doppler (at 2 different levels of cerebral blood flow	—

Countries

Netherlands

Outcome results