biobeschikbaarheid Bioavailability study
Conditions
Interventions
6 different study products will be investigated:
- 4 different proteins
- a mix of these proteins
- a tube feeding based on the protein mix
Sponsors
Nutricia Research B.V.
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age 65 years or older 2. BMI from 20 through 30 kg/m2 3. Willingness and ability to comply with the protocol 4. Written informed consent 5. Be judged by the investigator to be in good health.
Exclusion criteria
Exclusion criteria: 1. Any gastrointestinal (GI) disease or surgery that interferes with GI function 2. Known renal or hepatic failure 3. Known or suspected Diabetes Mellitus (fasting glucose level >= 7.0 mmol/L) 4. (History of) any cancer with the exception of basal cell carcinoma 5. Fever in the last 7 days prior to Visit 1 6. Haemoglobin in men
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome parameter in this study is the time to reach half incremental area under the curve (t* iAUC) for the sum of all amino acids (total AA). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome parameters of this study are: • The (incremental) maximum amino acid concentration ((i)Cmax), (incremental) area under the concentration curve ((i)AUC) and t* iAUC • Gastric emptying half time (t1/2), Cmax, and time until Cmax is reached (Tmax) and AUC • Satiety questionnaire | — |
Countries
Netherlands
Outcome results
None listed