Pre-implantation genetic haplotyping of embryos using next-generation sequencing

Pre-implantation genetic haplotyping of embryos using next-generation sequencing - PGD haplotyping

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42386

Enrollment

266

Registered

2015-12-22

Start date

2016-01-03

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chromosomal anomalies monogenic diseases

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Couple undergoed IVF/PGD treatment for a monogenic disease or chromosomal disorder (diagnosed by aCGH )

Exclusion criteria

Exclusion criteria: Couples unable to give informed consent to all aspects of the study or unable to comply with the protocol.

Design outcomes

Primary

Measure	Time frame
Research phase Percentage invalid results for monogenic disorders in blastomere cells and in trophectoderm cells for chromosomal disorders in in blastomere cells and in trophectoderm cells for chromosomalaneuploidy in blastomere cells and in trophectoderm cells Verification phase Sensitivity of the NGS-based haplotyping method for monogenic disorders in blastomere cells and in trophectoderm cells for chromosomal disorders in in blastomere cells and in trophectoderm cells for chromosomalaneuploidy in blastomere cells and in trophectoderm cells	—

Measure

Time frame

Research phase Percentage invalid results for monogenic disorders in blastomere cells and in trophectoderm cells for chromosomal disorders in in blastomere cells and in trophectoderm cells for chromosomalaneuploidy in blastomere cells and in trophectoderm cells Verification phase Sensitivity of the NGS-based haplotyping method for monogenic disorders in blastomere cells and in trophectoderm cells for chromosomal disorders in in blastomere cells and in trophectoderm cells for chromosomalaneuploidy in blastomere cells and in trophectoderm cells

—

Countries

Netherlands

Outcome results