arterial wall thickening atherosclerosis
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: patients: - aged 18 years or older - diagnosis of a known lipid disorder (including but not limited to hypercholestoremia, hypertriglyceridemia, combined hyperlipidemia, hypoalphalipoprotenemia, hypobetalipoprotenemia);Control group: - Age >18 years - No previous cardiovascular events - No medication use
Exclusion criteria
Exclusion criteria: Both groups: - Known malignant disorders or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator. - Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study. - History of cardiovascular event within the last 3 months - Clinical signs of acute infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - the expression of pro-atherogenic surface markers on monocytes - gene expression of genes involved in lipid processing | — |
Secondary
| Measure | Time frame |
|---|---|
| - Trans endothelial migration w - Lipid accumulation in monocytes - In vitro cytokine production - Epigenetic changes | — |
Countries
Netherlands
Outcome results
None listed