brain inflammation Limbic encephalitis
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Limbic encephalitis due to antibodies to LGI1, Caspr2, NMDAR, GABA-B or GAD65, recently or in the past - Current age > 18 years - Caucasoid race
Exclusion criteria
Exclusion criteria: - Not mentally competent to give informed consent - Patient is withholding informed consent, or objects after initial consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The frequency of HLA-A, B, C, DR and DQ alleles | — |
Secondary
| Measure | Time frame |
|---|---|
| If a specific HLA allele is detected in a subgroup of LGI1 patients, we will analyze whether there are specific patient characteristics or disease characteristics in this subgroup Amendement: analyze the relevant LGI1 epitope (fragment of the protein to which inflammatory cells bind) | — |
Countries
Netherlands
Outcome results
None listed