The effects of an extensive exercise program on the progression of mild cognitive impairment (MCI) and cerebral perfusion regulation

The effects of an extensive exercise program on the progression of mild cognitive impairment (MCI) and cerebral perfusion regulation - NeuroExercise

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON42347

Enrollment

Registered

2016-01-05

Start date

2016-03-07

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild cognitive impairment starting memory problems

Interventions

Patients are classified in 3 groups. One group receives a standardized one-year extensive aerobic exercise intervention (3 units à 45min / week, according to WHO recommendations). The second group r

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Diagnosis of Mild cognitive impairment (MCI) (Peterson criteria or practical identification) Physical ability sufficient to allow performance of endurance exercise training

Exclusion criteria

Exclusion criteria: Diagnosis of dementia/Alzheimer's disease Engagement in moderate-intensity aerobic exercise training for more than 30 minutes, 3 times per week, during past 2 years History of brain damage History of myocardial infarction Unstable chronical disease Uncontrolled hypertension

Design outcomes

Primary

Measure	Time frame
The primary outcome is cognitive performance, determined by a neuropsychological test battery.	—

Secondary

Measure	Time frame
Secondary outcomes are physical fitness, cerebral autoregulation, cerebrovascular reactivity, prefrontal oxygenation, arterial stiffness, endothelial function, quality of life, epigenetics and cerebral structure	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)