Expression of cytokeratins and notch in the healthy folliculopilosebaceous unit

Expression of cytokeratins and notch in the healthy folliculopilosebaceous unit - Keratin and Notch in the PSU

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42336

Enrollment

Registered

2015-08-19

Start date

2015-09-09

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acne ectopica acne inversa

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Subjects are not affected with HS - Subjects do not have another skin disease located at the armpits or groins - Age 18-50 years

Exclusion criteria

Exclusion criteria: - Subjects who have not given informed consent - Subjects with a skin disease located in the armpits and groins

Design outcomes

Primary

Measure	Time frame
The intensity of the stainings will be measured at the 6 segments of the FPSU: bulb, bulge, isthmus, sebofollicular junction, infundibulum and interfollicular epidermis. For each skin sample the intensity of all performed IF stainings at the aforementioned individual segments will be analyzed using Image J software.	—

Secondary

Measure	Time frame
The intensity of the stainings will be measured at the 6 segments of the FPSU: bulb, bulge, isthmus, sebofollicular junction, infundibulum and interfollicular epidermis. For each skin sample the intensity of all performed IF stainings at the aforementioned individual segments will be analyzed using Image J software. Next, the association between expression of the cytokeratins and Notch 1 will be examined. Notch 1 expression will be the independent variable, the expression of the different cytokeratins the dependent variable.	—

Measure

Time frame

The intensity of the stainings will be measured at the 6 segments of the FPSU: bulb, bulge, isthmus, sebofollicular junction, infundibulum and interfollicular epidermis. For each skin sample the intensity of all performed IF stainings at the aforementioned individual segments will be analyzed using Image J software. Next, the association between expression of the cytokeratins and Notch 1 will be examined. Notch 1 expression will be the independent variable, the expression of the different cytokeratins the dependent variable.

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Countries

Netherlands

Outcome results