disuse atrophy
Conditions
Interventions
7 days of bed-rest with continuous or intermittent nasogastric feeding.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Male * Aged from 18-35 years * 18.5
Exclusion criteria
Exclusion criteria: * Smoking * Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months * Hypertension (according to WHO criteria) [16] and/or cardiovascular disease * Any back/leg/knee/neck/postural complaints * Type 2 diabetes mellitus * Any family history of thrombosis * All co-morbidities interacting with mobility and muscle metabolism of the lower limbs * (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis). * Myocardial infarction within the last 3 years * Use of certain anti-coagulants (use of thrombocyte aggregation inhibitors such as Ascal, acetylsalicylic acid, aspirin and carbasalaatcalcium is permitted. Use of other thrombocyte aggregation inhibitors will be discussed with the responsible physician) * A history of deep vein thrombosis (DVT) in the leg * Having donated blood in the 3 months prior to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral insulin sensitivity (measured as glucose infusion rate, GIR) | — |
Secondary
| Measure | Time frame |
|---|---|
| Quadriceps cross-sectional area (CSA), whole body lean mass, leg lean mass, mitochondrial function, accumulated (7-day) free-living and bed-rested myofibrillar and mitochondrial fractional synthesis rates, nitrogen balance. | — |
Countries
Netherlands
Outcome results
None listed