arterial wall thickening Atherosclerosis
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Aged 50 years or older 2. Chronic Kidney Disease stages 3 and 4 (eGFR: 15-60 ml min-1)
Exclusion criteria
Exclusion criteria: 1. Malignant diseases or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator. 2. Standard contra-indications to 18F-FDG PET, and CT based on physicians experience and current practices: Claustrophobia, Metal in the body, as a result of e.g. osteosynthetic material, pacemaker implantation or artificial cardiac valves. 3. Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study. 4. Participation in a scientific study with radiation exposure in the year prior to inclusion. 5. Planned radiation exposure in the next year due to participation in a research project with radiation exposure or for clinical reasons. 6. Planned or expected diagnostic procedures with radiation exposure due to a medical condition 7. Clinical signs of acute infection and/or CRP>10 8. History of MI/Stroke or known coronary artery disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the 18F-FDG -PET/CT measurements of arterial wall inflammation (target-to-background ratio) compared to healthy control subjects. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the correlation between the degree of arterial wall inflammation as assessed with 18F-FDG -PET/CT and circulating markers of inflammation and renal failure. | — |
Countries
Netherlands
Outcome results
None listed