lung fibrosis Pulmonary fibrosis
Conditions
Interventions
Sponsors
Sint Antonius Ziekenhuis
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Patients with PF, visiting outpatient respiratory clinic at St Antonius Hospital in Nieuwegein (Expertise Centre Interstitial Lung disease, cIL) for routine medical control
Exclusion criteria
Exclusion criteria: Absolute contraindications Acute myocardial infarction (3-5 days); Unstable angina; Uncontrolled arrhythmias causing symptoms or haemodynamic compromise; Syncope; Active endocarditis; Acute myocarditis or pericarditis; Symptomatic severe aortic stenosis; Uncontrolled heart failure; Acute pulmonary embolus or pulmonary infarction; Thrombosis of lower extremities; Suspected dissecting aneurysm; Uncontrolled asthma; Pulmonary oedema; Acute respiratory failure; Acute noncardiopulmonary disorder that may affect exercise performance or be aggravated by exercise (i.e. infection, renal failure, thyrotoxicosis); Mental impairment leading to inability to cooperate;A subject that meets any of the following criteria, will be in- or excluded by the judge of the pulmonologist:;Relative contraindications Room air SpO2 at rest 85% (arterial oxygen saturation measured by pulse oximetry); Left main coronary stenosis or its equivalent; Moderate stenotic valvular heart disease; Severe untreated arterial hypertension at rest (200 mmHg systolic, 120 mmHg diastolic); Tachyarrhythmias or bradyarrhythmias; High-degree atrioventricular block; Hypertrophic cardiomyopathy; Significant pulmonary hypertension; Advanced or complicated pregnancy; Electrolyte abnormalities; Orthopaedic impairment that prevents walking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are: 4MGS - the maximum gait speed in meters per second (m/sec). 5STS - the shortest time (seconds) required to stand five times from sitting in a chair. 6WMT - the maximum walking distance (meters). | — |
Secondary
| Measure | Time frame |
|---|---|
| • SF-36 (IPF): 8 dimensions of Health-related quality of life. • MRC: a self administered questionnaire about perceived breathlessness. • Self efficacy: self reported activity limitation • Borg dyspnoe and Borg fatigue • Pulmonary function, baseline pulmonary test results: FVC, FEV1, DLCO • Oxygen saturation • Blood pressure (systolic/diastolic). • Body Mass Index (height / weight*weight). • Lean Body Mass (subtracting body fat weight from total body weight). • Grip strength (Jamar dynamometer). • Feasibility of performance tests (Likert scale), patient experience. • Utility of performance tests (Likert scale), assessor experience. | — |
Countries
The Netherlands
Outcome results
None listed