atrial fibrillation of unknown origin life-threatening ventricular rythm disorder of unknown origin
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with iVF: All documented patients with: • A sudden cardiac arrest with initial rhythm of VF. • Who were diagnosed with iVF after careful phenotyping and exclusion of all structural or primary electrical cardiac disease. • In whom regular genetic testing has not detected a known gene mutation associated with the occurrence of VF. ;Patients with (familial) lone AF • Patients with at least 1 episode of documented AF • No present structural or systemic cause for AF, excluded by past medical history, anamnesis, physical examination, laboratory results, electrocardiogram, X-thorax and echocardiography •
Exclusion criteria
Exclusion criteria: • Patients not capable of giving inform consent •
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The detection of the underlying genetic cause of patients with IVF and fAF by: 1. The evaluation of the genetic burden of pathogenic mutations in a diagnostic panel of 212 cardiomyopathy genes. 2. The detection of novel genes/genetic factors responsible for IVF and fAF. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The correlation of the presence of gene defects and response to catheter ablation in AF patients. 2. The understanding of the pathophysiological mechanism and disease pathways of iVF and familial lone AF with functional studies using the extensive UMCU network with collaboration of the departments of biostatistics, medical physiology, experimental cardiology and the Hubrecht institute. | — |
Countries
Netherlands
Outcome results
None listed