Treatment effects of a short intensive treatment (8 days) of obsessive compulsive disorder and panic disorder of nonresponders of cognitive behaviour therapy.

Treatment effects of a short intensive treatment (8 days) of obsessive compulsive disorder and panic disorder of nonresponders of cognitive behaviour therapy. - Short Intensive treatment for OCD and PD

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON42267

Enrollment

Registered

2014-12-31

Start date

2015-05-12

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obsessive compulsive disorder and panic disorder

Interventions

Treatment All patients receive the same intervention of ICBT with ERP. CBT is the treatment of choice for anxiety disorders (van Balkom et al., 2013). Intensive CBT (2-10 days) has been proven to be

Oldfield, et al., 2011) and for PD (e.g. Bitran, Morisette, Spiegel, & Barlow, 2008

Wambach & Relief, 2012). There will be additional family psycho-education sessions, for the adolescent patients. In the present study, intensive treatment will be delivered in 8 days (in two weeks)

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with a primary diagnosis (DSM IV) of obsessive-compulsive disorder or panic disorder, who had an adequate cognitive behaviour treatment and did not respond ((C)Y-BOCS score of al least 16 or a PDSS score of at least 11).

Exclusion criteria

Exclusion criteria: - Major depressive disorder and/or suicidality - Psychotic disorder - Bipolar disorder - Comorbid diagnosis Hoarding - Intellectual disability or severe cognitive function disorders - Inability to fill in questionary - Inability to focus on treatment because of other problems - Inability to reduse in alcohol or drugsuse Additional for adolescents: - Severe Comorbid Pervasive Developmental Disorder - Severe disrupted family functioning - Other problems or problem area's of first priority

Design outcomes

Primary

Measure	Time frame
Primary study parameters are: Adults: PDSS for PD The main PD symptoms are assessed with the PDSS: The Panic Disorder Severity Scale (Shear, et al., 1992; de Beurs, 2002). The PDSS is a 7 item semi-structured clinical interview. Symptoms of the last week are rated on a 5-points Likert scale, ranging from 0-4. The most important aspects of panic disorder (panic frequency, fear or distress during panic attacks, anticipatory anxiety, phobic avoidance of situations, phobic avoidance of physical sensations, impairment in work and social functioning. The (clinician-administered) PDSS is considered a reliable tool for monitoring of treatment outcome (Shear, et al., 2001). The scale can be administered in 10-15 minutes. Y-BOCS for OCD The main OCD symptoms are assessed with the Y-BOCS: the Yale-Brown Obsessive-Compulsive Scale (1989). The Y-BOCS is a 10-item semi-structured clinical interview. Symptoms of the last week are rated on a 5-points Likert scale, ranging from 0-4. The (clinician-administered) Y-BOCS is considered a reliable tool for monitoring of treatment outcome and is considered as the gold standard measure of obsessive-compulsive symptoms (Storch et al., 2005). The scale can be assessed in 15-30 minutes. Adolescents: CY-BOCS for OCD The main OCD symptoms are assessed with the CY-BOCS: the Child Yale-Brown Obsessive-Compulsive Scale (Scahill et al., 1997; de Haan & Wolters, 2007). The CY-BOCS is a 10-item semi-structured clinical interview. Symptoms of the last week are rated on a 5-points Likert scale, ranging from 0-4. The (clinician-administered) CY-BOCS is considered a reliable tool for monitoring of treatment outcome and is considered as the gold standard measure of obsessive-compulsive symptoms (Storch et al., 2005). The scale can be assessed in 15-30 minutes.	—

Measure

Time frame

Primary study parameters are: Adults: PDSS for PD The main PD symptoms are assessed with the PDSS: The Panic Disorder Severity Scale (Shear, et al., 1992; de Beurs, 2002). The PDSS is a 7 item semi-structured clinical interview. Symptoms of the last week are rated on a 5-points Likert scale, ranging from 0-4. The most important aspects of panic disorder (panic frequency, fear or distress during panic attacks, anticipatory anxiety, phobic avoidance of situations, phobic avoidance of physical sensations, impairment in work and social functioning. The (clinician-administered) PDSS is considered a reliable tool for monitoring of treatment outcome (Shear, et al., 2001). The scale can be administered in 10-15 minutes. Y-BOCS for OCD The main OCD symptoms are assessed with the Y-BOCS: the Yale-Brown Obsessive-Compulsive Scale (1989). The Y-BOCS is a 10-item semi-structured clinical interview. Symptoms of the last week are rated on a 5-points Likert scale, ranging from 0-4. The (clinician-administered) Y-BOCS is considered a reliable tool for monitoring of treatment outcome and is considered as the gold standard measure of obsessive-compulsive symptoms (Storch et al., 2005). The scale can be assessed in 15-30 minutes. Adolescents: CY-BOCS for OCD The main OCD symptoms are assessed with the CY-BOCS: the Child Yale-Brown Obsessive-Compulsive Scale (Scahill et al., 1997; de Haan & Wolters, 2007). The CY-BOCS is a 10-item semi-structured clinical interview. Symptoms of the last week are rated on a 5-points Likert scale, ranging from 0-4. The (clinician-administered) CY-BOCS is considered a reliable tool for monitoring of treatment outcome and is considered as the gold standard measure of obsessive-compulsive symptoms (Storch et al., 2005). The scale can be assessed in 15-30 minutes.

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Secondary

Measure	Time frame
Adults: IDS Depressive symptoms are assessed with the IDS: Inventory of Depressive Symptomatology (Rush et al., 2000). The IDS contains 30 items with a 4-point Likert Scale. In the present study the Self Rating version is used. The IDS has good validation (Rush et al., 1996). The scale can be assessed in 10 minutes. OQ The Outcome Questionnaire (OQ-45.2) is a 45-item self-report scale designed for repeated measurement of client functioning through the course of therapy and at termination. The instrument has proven particularly useful in documenting the effect of interventions due to therapy as it has been shown to be sensitive to change in a treated population while remaining stable in a nontreated population (Lambert, Burlingame, et al., 1996). MINI The Mini International Neuropsychiatric Interview (MINI; Sheehan et al., 1998; Overbeek et al., 1999) is a short diagnostic structured interview (DSI) developed in France and the United States to explore 17 disorders according to Diagnostic and Statistical Manual (DSM)-III-R diagnostic criteria (Sheehan et al., 1998; Overbeek, 2006) . It is fully structured to allow administration by non-specialized interviewers.MINI is a short diagnostic interview schedule that can be easily incorporated into routine clinical interviews. It has good acceptance by patients (Pinninti et al., 2003). In order to keep it short it focuses on the existence of current disorders. For each disorder, one or two screening questions rule out the diagnosis when answered negatively. CGI The Clinical Global Impression Scale (CGI; Guy, 1976) is a 3-item questionnaire designed to assess global severity of illness and change in the clinical condition over time. The CGI consists of three global scales: 1) severity of illness; 2) global improvement; 3) efficacy index. The clinical Global Impression Scale (CGI) is commonly used as a primary outcome measure in studies evaluating the efficacy of treatments for anxiety disorders	—

Measure

Time frame

Adults: IDS Depressive symptoms are assessed with the IDS: Inventory of Depressive Symptomatology (Rush et al., 2000). The IDS contains 30 items with a 4-point Likert Scale. In the present study the Self Rating version is used. The IDS has good validation (Rush et al., 1996). The scale can be assessed in 10 minutes. OQ The Outcome Questionnaire (OQ-45.2) is a 45-item self-report scale designed for repeated measurement of client functioning through the course of therapy and at termination. The instrument has proven particularly useful in documenting the effect of interventions due to therapy as it has been shown to be sensitive to change in a treated population while remaining stable in a nontreated population (Lambert, Burlingame, et al., 1996). MINI The Mini International Neuropsychiatric Interview (MINI; Sheehan et al., 1998; Overbeek et al., 1999) is a short diagnostic structured interview (DSI) developed in France and the United States to explore 17 disorders according to Diagnostic and Statistical Manual (DSM)-III-R diagnostic criteria (Sheehan et al., 1998; Overbeek, 2006) . It is fully structured to allow administration by non-specialized interviewers.MINI is a short diagnostic interview schedule that can be easily incorporated into routine clinical interviews. It has good acceptance by patients (Pinninti et al., 2003). In order to keep it short it focuses on the existence of current disorders. For each disorder, one or two screening questions rule out the diagnosis when answered negatively. CGI The Clinical Global Impression Scale (CGI; Guy, 1976) is a 3-item questionnaire designed to assess global severity of illness and change in the clinical condition over time. The CGI consists of three global scales: 1) severity of illness; 2) global improvement; 3) efficacy index. The clinical Global Impression Scale (CGI) is commonly used as a primary outcome measure in studies evaluating the efficacy of treatments for anxiety disorders

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)