Is step initiation during improbable events affected in PD with or without FOG? An explorative study.

Is step initiation during improbable events affected in PD with or without FOG? An explorative study. - Step initiation in Parkinson's disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42242

Enrollment

Registered

2015-03-10

Start date

2015-02-26

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Men/women of age > 60 years • Can provide written informed consent • For participants with Parkinson*s disease: Idiopathic Parkinson*s disease, according to the UK Brain Bank Criteria (Hughes et al., 1992) • For participants with PD and FOG: Presence of FOG (Subjectively: defined as a score of 1 on question *Have you experienced FOG in the past month* from the NFOGQ, and, objectively: objectively measured observed at any time by a neurologist or during previous experiments) • For both PD groups: Clinically worsened (as measured by UPDRS) during OFF state (Galea et al., 2012) • Able to walk without an aid, even when off dopaminergic medication

Exclusion criteria

Exclusion criteria: - Presence of any other neurological disorders such as stroke or epilepsy or psychiatric disease - Pain, and or major outstanding musculoskeletal/ orthopaedic conditions in their lower limbs or back (pain that prevents independent performance of an activity of daily living) - Dyslexia (or unable to read and write) - Visual impairments which would affect seeing the screen in the balance lab - Uncontrolled diabetes or thyroid problems - History of severe, frequent headaches - Dementia (cognitive impairment): TICs-m score of 4 (Weintraub et al., 2006, D'Ath et al., 1994) - Patients with deep brain stimulation - Polineuropathy

Design outcomes

Primary

Measure	Time frame
Average Reaction Time: defined as the average time from appearance of the visual stimulus to first unloading of any leg (Creath et al., 2013).	—

Secondary

Measure	Time frame
- Step Length: defined as the distance from step onset to end of step. - Step Duration: defined as the time from step onset to end of step. - Anticipatory Postural Adjustments: defined as the maximum increase in vertical force directed towards the stepping leg, normalized for body weight and corrected for the amount of loading (Mensink et al., 2014). - Learning Rate: The time taken to reach 95% errorless performance. This will be measured only during training.	—

Measure

Time frame

- Step Length: defined as the distance from step onset to end of step. - Step Duration: defined as the time from step onset to end of step. - Anticipatory Postural Adjustments: defined as the maximum increase in vertical force directed towards the stepping leg, normalized for body weight and corrected for the amount of loading (Mensink et al., 2014). - Learning Rate: The time taken to reach 95% errorless performance. This will be measured only during training.

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Countries

Netherlands

Outcome results