Monitoring radiation induced cardiac damage by blood markers

Monitoring radiation induced cardiac damage by blood markers - CARD study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42221

Enrollment

Registered

2015-04-23

Start date

2015-09-09

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

radiation induced cardiac damage

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: patients with esophageal or non small cell lung cancer with an curative indication for radiotherapy, with or without chemotherapy, with or without surgery.

Exclusion criteria

Exclusion criteria: prior radiotherapy to the chest, treatment with palliative intent

Design outcomes

Primary

Measure	Time frame
Percentage of rise of the level of NT pro BNP after radiotherapy	—

Secondary

Measure	Time frame
• A new diagnosis of: heart failure, myocardial infarction or a newly diagnosed rhythm disorder will be scored as a cardiac event. Myocardial ischaemia requiring intervention and changes in cardiac medication in case of deterioration of known heart failure will be analysed by a cardiologist to decide whether or not to score this as an event. Events will be scored according the CTCAE 4.2 criteria. • Percentage of rise of hs-TNT during or after treatment	—

Measure

Time frame

• A new diagnosis of: heart failure, myocardial infarction or a newly diagnosed rhythm disorder will be scored as a cardiac event. Myocardial ischaemia requiring intervention and changes in cardiac medication in case of deterioration of known heart failure will be analysed by a cardiologist to decide whether or not to score this as an event. Events will be scored according the CTCAE 4.2 criteria. • Percentage of rise of hs-TNT during or after treatment

—

Countries

Netherlands

Outcome results