Coherence Analyses in Hyperkinetic Movement Disorders

Coherence Analyses in Hyperkinetic Movement Disorders - Coherence Analyses HMD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42214

Enrollment

Registered

2014-12-18

Start date

2015-01-09

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dystonia essential tremor. Hyperkinetic movement disorders

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Patients with Dystonia (DYS) or Parkinson's Disease (PD) who will be treated with DBS, and Essential Tremor (ET) patients with DBS in which the stimulator will be replaced operatively. 2. 18 years and older. 3. life expectancy longer than one year

Exclusion criteria

Exclusion criteria: Any condition with a life expectancy less then 1 year, which would result in incomplete follow-up.

Design outcomes

Primary

Measure	Time frame
In all patients: Relation between LFP-EMG coherence and clinical effect of DBS quantified by the difference pre- and post-surgery on the specific movement disorder rating scales.	—

Secondary

Measure	Time frame
In DYS: Cortico-muscular (EEG-EMG), intra-muscular (EMG-EMG) coherence, and Burke-Fahn-Marsden dystonia rating scale (BFMDRS) values pre- and post-DBS-surgery. In PD: Cortico-muscular (EEG-EMG + accelerometer) coherence, intra-muscular (EMG-EMG), and tremor severity assessed with tremor items of the motor (third) part of the unified Parkinson's disease rating scale (UPDRS) values pre- and post-DBS-surgery.	—

Measure

Time frame

In DYS: Cortico-muscular (EEG-EMG), intra-muscular (EMG-EMG) coherence, and *Burke-Fahn-Marsden dystonia rating scale* (BFMDRS) values pre- and post-DBS-surgery. In PD: Cortico-muscular (EEG-EMG + accelerometer) coherence, intra-muscular (EMG-EMG), and tremor severity assessed with tremor items of the motor (third) part of the unified Parkinson's disease rating scale (UPDRS) values pre- and post-DBS-surgery.

—

Countries

Netherlands

Outcome results