Gastroesophageal reflux disease heartburn
Conditions
Interventions
Capsaicin infusion and control infusion.
Capsaicin
GERD
Heartburn
TRPV1
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Healthy subjects I. No history of gastrointestinal disease, especially gastro-esophageal reflux disease. II. BMI
Exclusion criteria
Exclusion criteria: Healthy subjects I. Age 1 x per week) dietary capsaicin or red pepper containing foods. IV. Use of medication affecting GI function (prokinetics) or antisecretory medication (PPI) within 3 days prior to endoscopy. V. Multisystem diseases (including severe cardiopulmonary disease, collagen diseases, coagulation disorders) VI. Esophageal motility disorders VII. Previous esophageal or gastric surgery VIII. Use of anticoagulants or a history of coagulopathy IX. Pregnancy X. History of alcohol abuse or current excessive alcohol consumption (> 2 alcoholic beverages per day or > 14 alcoholic beverages per week). XI. No allergies for capsaicin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Baseline impedance as measured in vivo after infusion with capsaicin and control solution. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Intercellulair spaces using electron microscopy ruimte met elektronen microscoop 2. Mucosal concentration of neuropeptides 3. Immunohistochemical expression of TRPV1 4. VAS scores for heartburn, retrosternal pain. | — |
Countries
The Netherlands
Outcome results
None listed