neurodegenerative aandoeningen (vasculair) Cerebral amyloid angiopathy small vessel disease
Conditions
Interventions
Biomarkers
Cerebral amyloid angiopathy
Cerebrospinal fluid
Imaging
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for sporadic CAA group: - Fulfilment of the modified Boston criteria for Cerebral Amyloid Angiopathy (CAA);Inclusion criteria for late-onset AD group: - Fulfillment of the diagnostic criteria - Available T2* MRI scan with information on presence or absence of CAA;Inclusion criteria for RUNDMC participants: - Participants in the ongoing RUNDMC study (PI dr. FE de Leeuw) will be selected for the likelihood of the presence or absence of CAA, based on T2* MRI investigations that are already available.
Exclusion criteria
Exclusion criteria: Exclusion criteria for MRI: - Metal parts in the body (pacemaker, neurostimulator, clips, medication pumps, port-a-cath, hearing aids, cochlear implants, prostheses, piercings) - Claustrofobia - Difficulty with lying down for more than 30 minutes - Pregnancy ;Exclusion criteria for Lumbar puncture: - Allergy to local anesthetic agents - Medical history of compression of spinal cord, spinal surgery, skin infection, developmental abnormalities in lower spine, blood coagulopathy, anticoagulant medication. - Clinical (or previous MRI) evidence of structural (space occupying) cerebral abnormalities that are not compatible with the performance of an LP including malignancies, abscess or obstructive hydrocephalus.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • develop and validate sensitive and specific body fluid and neuroimaging biomarkers to detect CAA during life. | — |
Secondary
| Measure | Time frame |
|---|---|
| • correlate novel neurochemical and neuroimaging biomarkers with each other and with measures of cognitive decline | — |
Countries
The Netherlands
Outcome results
None listed