blood sugar values insulin sensitivity
Conditions
Interventions
2 activity regimes of 4 days: a sitting regime and a "sit less" regime
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: o Signed informed consent o Men and postmenopausal women: 40-80 years old o BMI: 25.0 - 35.0 kg/m2 o Maximum 2.5 hours of MVPA per week (during last 3 months) o Having a general practitioner o Agreeing to be informed about medically relevant personal test-results by a physician o Accessible veins on arms as determined by examination at screening
Exclusion criteria
Exclusion criteria: o Reported participation in another biomedical trial which may have an effect on insulin sensitivity one month before the pre-study examination or during the study o Blood donation in the past three months o Reported participation in night shift work 2 weeks prior to pre-study investigation or during the study. Night work is defined as working between midnight and 6.00 AM. o Consumption of >14 (women) or > 21 (men) alcoholic units per week o Reported dietary habits: medically prescribed diet, slimming diet; o Reported weight loss (>2kg) in the last three months prior to the screening; o Not being able to execute at least three (out of four) cognition tests in the training session o Not being able to execute the sit less try-out day o Being an employee of Unilever or the collaborating research departments in Maastricht University Medical Centre o Experimental drug use (during the last 3 months) o Use of insulin, oral blood glucose lowering medication (metformin and/or SU-derivatives and/or DPP-IV inhibitors), corticosteroids or vitamin K antagonists in the last 3 months o Fasting plasma glucose level > 6.9 mmol/L o Medical conditions which make participation in the study not responsible which will be decided by a medical doctor during screening o Other clinically relevant abnormalities in clinical chemistry at screening (to be judged by a medical doctor) o Mental or physical disability which interferes with physical activity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • To assess the effect of low intensity physical activity (LIPA) on plasma insulin levels (as measured as area under the curve during an oral glucose tolerance test) | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives: • To assess the effect of LIPA on insulin sensitivity • To assess the effect of LIPA on plasma C-peptide and glucose levels • To assess the effect of LIPA on lipid metabolism • To assess the effect of LIPA on mood and cognitive performance • To assess the effect of LIPA on Quality of Life and sleep • To explore the association between plasma glucose, plasma insulin, insulin sensitivity and mood, cognitive performance, Quality of Life and sleep • To assess the effect of LIPA on inflammation and endothelium • To assess the effect of LIPA on blood pressure • Insulin like growth factor 1 (IGF-1) and growth hormone (GH) | — |
Countries
Netherlands
Outcome results
None listed