Effect of Statins on epigenetic reprogramming of monocytes in patients with elevated levels of LDL: an observational study

Effect of Statins on epigenetic reprogramming of monocytes in patients with elevated levels of LDL: an observational study - Statins and trained immunity

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42146

Enrollment

Registered

2014-12-09

Start date

2015-06-04

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dyslipidemia high cholesterol hypercholsterolemia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Elevated levels of LDL in the blood (LDL >4.9 mmol/l) Age > 18 years

Exclusion criteria

Exclusion criteria: - Current lipid lowering treatment - Previous cardiovascular events - Known malignant disorders or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator. - Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study. - Clinical signs of acute infection

Design outcomes

Primary

Measure	Time frame
Epigenetic changes in the promotor regions of pro-inflammatory cytokines in monocytes before and after statin treatment	—

Secondary

Measure	Time frame
cytokine release upon stimulation with TLR agonists and ex vivo characterization of monocytes	—

Countries

Netherlands

Outcome results