algehele en metabole gezondheid fatty liver glucose metabolism vascular health
Conditions
Interventions
A twelve week intervention of either 98g whole grain wheat (WGW) or a control
intervention of refined wheat (RW) in the form of 4 slices of bread and 2
servings of ready to eat cereals (RTEC).
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet the following inclusion criteria: Males or postmenopausal females (target 50: 50 for both genders) For females: menstrual cycle absent for more than 1 year Age 45-70yrs BMI between 25 and 35 kg/m2 Signed informed consent Normal food habit of bread and cereal consumption
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: • Not having a general practitioner • Having a history of medical or surgical events that may affect the study outcome • Smoker • Use of cholesterol lowering medication • Mental status that is not compatible with proper conduct of the study • Aversion, intolerance to gluten, whole wheat or other items in the intervention products • Alcohol consumption of > 21 glasses a week • Abuse of drugs • Recent use of antibiotics ( 5 kg in the month prior to pre-study screening • Reported slimming or medically prescribed diet • Reported vegan or macrobiotic life-style • Not willing to give up blood donation during the study • Personnel of Wageningen University, department of Human Nutrition, their partner and their first and second degree relatives • Current participation in other research • Contraindication for MRI • Having blood vessels that make it difficult for inserting a cannula
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is cardiovascular/ cardio-metabolic health Blood markers include cholesterol, triglycerides, glucose, insulin, lipid profiles, glucagon, oxidized LDL, C-peptide, GIP, GLP-1, HbA1c, plasma adhesion molecules and markers of inflammation. Flow-mediated dilatation (FMD), blood pressure, Pulse Wave Analysis (PWA) and white blood cell count and activation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include liverfat, abdominal fat distrubution, liver- and adipose tissue health,mood questionnaires and do-it-yourself (DIY) devices in quantifying health effects in a nutritional intervention study. | — |
Countries
Netherlands
Outcome results
None listed