Tourette syndrome
Conditions
Interventions
None listed
Sponsors
HagaZiekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Fulfill DSM IV criteria for Tourette syndrome Born before January 1965
Exclusion criteria
Exclusion criteria: Diagnosis of dementia Severe psychiatric disorders (e.g. psychosis) Aphasia Not able to speak and/or read Dutch language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure is the total tic severity score on the Dutch version of the Yale Global Tic Severity Scale (YGTSS). The YGTSS is a well-established, semi-structured clinician derived rating scale with satisfactory convergent and discriminant validity and interrater agreement. Information on tic severity is acquired for motor tics and vocal tics separately in five dimensions: number, frequency, intensity, complexity, and interference. These dimensions are summated and the subscale scores are obtained. A rating of impairment is added to provide a total tic severity score that ranges from 0 (no tics) to 55 (severe tics). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measurements include general assessment of quality of life, severity of premonitory urges and severity of comorbidity. The presence of neuropsychiatric comorbidity will be assessed by a validated mini neuropsychiatric interview (M.I.N.I.). If ADHD is present, severity is measured with the Conners' Adult ADHD Rating Scales (CAARS). In case of comorbid OCD, the Yale Brown Obsessive Compulsive Scale is administered. Autism is measured with the Autism Spectrum Quotient. Depression will be measured using the Beck Depression Inventory Scale. Co-occurrence of migraine will be assessed using a semi-structured headache questionnaire. Quality of life is measured using the Gilles de la Tourette Syndrome*Quality of Life Scale. The GTS-QOL is a 27-item, patient-reported scale which measures GTS-specific health related quality of life on 4 subscales (psychological, physical, obsessional, and cognitive subscale). The GTS-QOL demonstrated satisfactory scaling assumptions and acceptability, high internal consistency high reliability and test-retest reliability, and supported validity. It takes into account the complexity of the clinical picture of GTS. Health related quality of life (HRQOL) will be assessed using the TNO-AZL questionnaire for Adult*s HRQOL (TAAQOL). This questionnaire measures health status problems weighted by the impact of problems on well-being on 12 multi-item scales: gross motor functioning, fine motor functioning, cognitive functioning, sleep, pain, social functioning, daily activities, sexuality, vitality, positive emotions, depressive emotions and aggressiveness. Higher scores indicate a better HRQOL (range 0-100). Scores will be compared with an age-matched Dutch reference group provided by TNO. Psychometric performance (reliability and validity) of the TAAQOL is satisfactory. | — |
Countries
Netherlands
Outcome results
None listed