Functional magnetic resonance imaging of human hypothalamic responses to glucose, fructose, sucrose, and sucralose.

Functional magnetic resonance imaging of human hypothalamic responses to glucose, fructose, sucrose, and sucralose. - fMRI of hypothalamic response to sugars and sweetners

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42119

Enrollment

Registered

2015-01-26

Start date

2015-02-17

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gezonde vrijwilligers healthy volunteers

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Signed informed consent -Age between 18 and 25 years -BMI between 20 and 24kg/m2 -Length between 170 and 190 centimeters

Exclusion criteria

Exclusion criteria: -Diabetes -Any genetic or psychiatric disease (e.g. fragile X syndrome, major depression) affecting brain -Any significant chronic disease -Renal or hepatic disease -Recent weight changes or attempts to lose weight (> 3 kg weight gain or loss, within the last 3 months) -Smoking (current or last 6 months) -Alcohol consumption of more than 21 units per week or use of recreational drugs at present or in the last year -Recent blood donation (within the last 2 months) -Recent participation in other biomedical research projects (within the last 3 months), participation in 3 or more biomedical research projects in one year -Contra-indication to MRI scanning

Design outcomes

Primary

Measure	Time frame
BOLD signal intensity changes of the hypothalamus after ingestion of 5 different stimuli of 300ml each: tap water, 50gr glucose solution, 50 gr fructose solution, 50gr sucrose solution and 0,1gr sucralose solution.	—

Secondary

Measure	Time frame
Psychophysical ratings of hunger, taste and sweetness	—

Countries

Netherlands

Outcome results