How to activate your lazy fat and move your muscle molecules? The influence of exercise training on RNA expression in adipose tissue and skeletal muscle in obese humans

*How to activate your lazy fat and move your muscle molecules? The influence of exercise training on RNA expression in adipose tissue and skeletal muscle in obese humans* - Exercise and RNA expression in adipose tissue and muscle

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON42108

Enrollment

Registered

2015-01-29

Start date

2015-03-24

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

insulin resistance Obesity

Interventions

8-week exercise training intervention

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - age 18 years of older - body mass index > 28 kg/m2

Exclusion criteria

Exclusion criteria: - Use of medication interfering with fat metabolism (thiazolidinediones) - Type 1 or 2 diabetes mellitus - Smoking

Design outcomes

Primary

Measure	Time frame
- RNA expression levels in subcutaneous adipose tissue (i.e. fat biopsy and subsequent transcriptome analysis) - RNA expression levels in skeletal muscle (i.e. muscle biopsy and subsequent transcriptome analysis)	—

Secondary

Measure	Time frame
- Insulin sensitivity (hyperinsulemic, euglycemic clamp) - Levels of adipokines and cytokines and levels of macrophage infiltration in subcutaneous adipose tissue - Levels of cytokines and myokines in skeletal muscle - Circulating inflammatory markers, adipokines and myokines (venous blood sampling) - Cardiovascular risk markers (venous blood sampling) - Brachial artery endothelial function (non-invasive vascular echography) - Carotid artery intima-media thickness (non-invasive vascular echography)	—

Measure

Time frame

- Insulin sensitivity (hyperinsulemic, euglycemic clamp) - Levels of adipokines and cytokines and levels of macrophage infiltration in subcutaneous adipose tissue - Levels of cytokines and myokines in skeletal muscle - Circulating inflammatory markers, adipokines and myokines (venous blood sampling) - Cardiovascular risk markers (venous blood sampling) - Brachial artery endothelial function (non-invasive vascular echography) - Carotid artery intima-media thickness (non-invasive vascular echography)

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)

*How to activate your lazy fat and move your muscle molecules? The influence of exercise training on RNA expression in adipose tissue and skeletal muscle in obese humans*