Juvenile idiopathic arthritis juvenile rheumatoid arthritis
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: - Age between 6 to 17 years - Ability to speak and understand Dutch - having been diagnosed with active JIA by their treating physician as defined by the ILAR-classification - having the most severe arthritis in either face, hand, knee or foot
Exclusion criteria
Exclusion criteria: - monoarthritis of the hip - serious injury to the body regions to be tested - Health problems such as Cystic Fibrosis, cancer, inflammatory bowel disease, drug or alcohol abuse; severe psychiatric disorder or dysfunction (e.g., major depression or generalized anxiety disorder requiring medical treatment) - Inability to understand the instructions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint is the difference in pain rating between baseline, i.e. time of diagnosis, (t0) and at 3 (t1), 6 (t2) and 12 months (t3) after diagnosis, dichotomized in clinical relevant change of VAS-score, defined by a change in VAS score of either >= 20 mm or >= 30%. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are: 1. monocyte/macrophage GRK2 expression 2. LPS-induced monocyte p38 activation 3. cytokine profiles (ratio between pro- and anti-inflammatory cytokine responses) 4. QST profile 5. pain favouring cognition 6. medication (subgroups of medication, NSAID's, MTX, TNF-a blocking biologicals, non-TNF-a blocking biologicals), as a proxy of severity and duration of active JIA | — |
Countries
Netherlands
Outcome results
None listed